Meet 15 women who have created and defined contemporary American culture. This documentary features intimate interviews with Madeleine Albright, Gloria Allred, Laurie Anderson, Sara Blakely, Margaret Cho, Edie Falco, Elizabeth Holmes, Betsey Johnson, Alicia Keys, Aimee Mullins, Nancy Pelosi, Rosie Perez, Shonda Rhimes, Wendy Williams and Nia Wordlaw. All trailblazers in their respective fields, these women share their experiences struggling against discrimination and overcoming challenges to make their voices heard and their influence felt.